Nicotiana tabacum is a perennial in the tropics and sub-tropics. If they are not exposed to a hard freeze that kills the roots, they will come up year after year from the roots. Even here in southwest Virginia, I had some roots sprout the following spring, after an unusually mild winter.
Consider 3 year old chicken or 6 year old beef. With meat animals, we slaughter them at a relatively young age, because the quality of the meat is more likely to be what we hope for. Meat from older animals is perfectly nutritious and healthy, but it is not as tender, and would cost much more per pound (multi-years of feeding and care vs. 1 year of feeding and care).
The plants that I maintained for several years were kept in tiny pots. I can't speak for the quality of what you would get from multi-year matured plants.
Another issue is pests. Once the plants have spent a season in the field, they are all likely to have some degree of pest burden that would probably persist into later years. And if you just leave them in the ground (in a suitable climate), crop rotation becomes problematic.
Finally, it would seem to be far less work to grow fresh plants each year, than to fuss with the huge root ball and supplemental soil that would be needed for potting mature plants.
With a second crop of suckers, you might get something worthwhile and you might not, but it entails little additional work beyond pest management and harvesting. The same return on effort expended is not the case with potting each mature plant to bring indoors over the winter.
We all learn from new experiments. Give it a try on, say 1/2 dozen plants, and let us know how it works out.
Bob