nornicotine, especially in air cured burley, is converted to TSNAs (tobacco-specific nitrosamines) which are the WORST tobacco-specific carcinogens. that is why the industry works to cull out the high converter plants (the mutation in currently available materials is unstable and will always revert to converting). a tobacco-specific carcinogen results from compounds that only tobacco plants naturally produce, not chemicals used in production (often also used in other crops). cellulose, present in all plants, is also turned into a carcinogen when it is burned, but it is a drastically less potent carcinogen than TSNAs.
I agree with most TSNA's being carcinogens. My point is that nornicotine also is most likely responsible for the approximate 50% reduction in Alzheimer's disease that smokers enjoy. Why do we universally condem nornicotine? I'm pretty sure ( if I remember right) that nornicotine is also a very potent analgesic. There are many substances that have both good and bad properties. The carcinogenic affects of TSNAs can easily be mitigated by ingesting Vitamin C. I understand the need for Industry to zero in on a "culprit" and attempt to do something about it but at the same time Big Tobacco demands LC tobacco only to then add 300 plus toxic chemicals to it.