I don't know. If there's no research on the matter, aside from that of other solanacea, I would assume it is an issue.
There was a documentary on CBC regarding research into certain weeds found on the prairies that may apply. They discovered that since the practice of stubble burning disappeared, the weeds have been a significantly greater problem. The reason is related to hormones released by the weeds that suppress the growth of the agricultural crops. The researchers conducted an experiment where they mixed activated charcoal into the soil of some pots and no charcoal in other pots. The pots were planted with these weeds, and with whatever the agricultural plant was. Sorry, I can't recall the species. Anyway, the pots with charcoal showed no inhibition of growth.
So, my suggestion is to experiment with this technique, rather than to abandon the area for planting tobacco.